Shushan A, Rojansky N, Laufer N, Klein BY, Shlomai Z, Levitzki R, Hartzstark Z, Ben-Bassat H. The AG1478 tyrosine kinase inhibitor is an effective suppressor of leiomyoma cell growth. Regulation of hypoxia inducible factor 1 alpha expression and function by the mammalian target of rapamycin. Association between tumor necrosis factor α and uterine fibroids: A protocol of systematic review. Yoshida S, Ohara N, Xu Q, Chen W, Wang J, Nakabayashi K, Sasaki H, Morikawa A, Maruo T. Semin Reprod Med. Insulin-like growth factor binding proteins—an update. Uterine leiomyomas (fibroids) are the most common pelvic tumor in women . Pathogenesis of Uterine Leiomyoma.. Risk Factors. Uterine fibroids (also called leiomyomas) are growths made up of the muscle and connective tissue from the wall of the uterus. Adenomyosis is a commonly diagnosed estrogen-dependent gynecological disorder that causes pelvic pain, abnormal uterine bleeding, and infertility. Tran FH, Zheng JJ. Molecular and clinical significance of fibroblast growth factor 2 (FGF2/bFGF) in malignancies of solid and hematological cancers for personalized therapies. Dysregulation of IGF-I signaling in uterine leiomyoma. This review article summarizes the current knowledge about alcohol-related pathogenesis of uterine fibroids (UFs) and highlights the molecular mechanisms that contribute to the development of UFs in response to alcohol consumption. Mod Pathol. mTOR signaling confers resistance to targeted cancer drugs. Ishikawa H, Ishi K, Serna VA, Kakazu R, Bulun SE, Kurita T. Endocrinology. 2002;84:431–6. They are most common in women of African descent and in women who have not borne children, and they are most often identified in women aged 30–45 years. 2004;19:1957–67. Oncogene. 2002;22:7004–701. Uterine fibroids (UFs), also known as uterine leiomyomas, are benign smooth muscle neoplasms of the uterus that affect women of reproductive age. Platelet-derived growth factor C is upregulated in human uterine fibroids and regulates uterine smooth muscle cell growth. Peng Y, Laser J, Shi G, Mittal K, Melamed J, Lee P, Wei JJ. Obstet Gynecol. 2012 Jul 25;358(2):223-31. doi: 10.1016/j.mce.2011.05.044. Tumors occur in ∼77% of women overall and are clinically manifest in ∼25% by age 45 years. 1998;394:485–90. 2008;89:468–71. The aim of this review is to summarize recent human and experimental … Int J Mol Med. Englund K, Lindblom B, Carlström K, Gustavsson I, Sjöblom P, Blanck A. Gene expression and tissue concentrations of IGFI in human myometrium and fibroids under different hormonal conditions. The effects and costs of laparoscopic versus abdominal myomectomy in patients with uterine fibroids: a systematic review and meta-analysis. Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas. Obesity is also associated with alterations in metabolic control such as those seen in insulin receptors and insulin-like growth factors, which have been linked to uterine fibroids. Borahay MA, Al-Hendy A, Kilic GS, Boehning D. Signaling pathways in leiomyoma: understanding pathobiology and implications for therapy. Uterine fibroids (leiomyomas or benign tumors of the smooth muscle) represent the most common form of benign mesenchymal disease of the female genital tract. Progesterone receptor A and B protein expression in human breast cancer. Showkat M, Beigh MA, Andrabi KI. Cold Spring Harb Perspect Biol. J Clin Endocrinol Metab. MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas. Schlaff WD, Zerhouni EA, Huth JA, Chen J, Damewood MD, Rock JA. The role of ovarian steroid hormones in the pathogenesis of uterine fibroids is supported by epidemiological, clinical, and experimental evidence. Adv Exp Med Biol. 2012;7(6):e40015. | Matsumura A, Kubota T, Taiyoh H, Fujiwara H, Okamoto K, Ichikawa D, Shiozaki A, Komatsu S, Nakanishi M, Kuriu Y, Murayama Y, Ikoma H, Ochiai T, Kokuba Y, Nakamura T, Matsumoto K, Otsuji E. HGF regulates VEGF expression via the c-Met receptor downstream pathways, PI3K/Akt, MAPK and STAT3, in CT26 murine cells. J Biol Chem. Hum Reprod. Fernig DG, Gallagher JT. Maruo T, Ohara N, Wang J, Matsuo H. Sex steroidal regulation of uterine leiomyoma growth and apoptosis. Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, Nordenskjöld M, Gustafsson JA. Biol Reprod. Hsieh YY, Wang YK, Chang CC, Lin CS. 2006;88:141–6. Bulun SE, Simpson ER, Word RA. Levin ER. 2000). Mol Biol Int. 2008;68:4719–26. Nowak RA. Szotek PP, Chang HL, Zhang L, Preffer F, Dombkowski D, Donahoe PK, Teixeira J. Prog Growth Factor Res. Membrane progesterone receptor expression in mammalian tissues: a review of regulation and physiological implications. Uterine fibroids are the most common benign tumors in women of childbearing age. Ikushima H, Miyazono K. TGFbeta signalling: a complex web in cancer progression. Shynlova O, Dorogin A, Lye SJ. USA.gov. Stretch-induced uterine myocyte differentiation during rat pregnancy: involvement of caspase activation. Although research in this area has been lacking in the past, much has been learned about this extremely common public health problem during the last 20 years (McBride 1999; Newbold et al. Transforming growth factor-beta3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation. 2004;89:5661–8. 2011;334:252–5. Pathogenesis of Endometriosis and Uterine Fibroids Pasquapina Ciarmela , 1 , * Hilary Critchley , 2 Gregory M. Christman , 3 and Fernando M. Reis 4 1 Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Via Tronto 10 A, 60020 Ancona, Italy Introduction. 2012;7:e33251. 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Immunohistochemical localization of growth factors and their receptors in uterine leiomyomas and matched myometrium. On the surgical front, uterine artery embolization. mTOR signaling in protein translation regulation: implications in cancer genesis and therapeutic interventions. Pathogenesis of uterine leiomyomas . Constitutive activation with overexpression of the mTORC2-phospholipase D1 pathway in uterine leiomyosarcoma and STUMP: morphoproteomic analysis with therapeutic implications. High aromatase expression in uterine leiomyoma tissues of African-American women. Higashiyama S, Abraham JA, Miller J, Fiddes JC, Klagsbrun M. A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Introduction. 1990;265:7709–12. Cell. Uterine fibroids (UFs), also known as uterine leiomyomas, are benign smooth muscle neoplasms of the uterus that affect women of reproductive age. Schematic diagram of uterine fibroid pathophysiology with. In the recent years, significant progress has been made in our understanding of fibroid tumorigenesis. The role of ovarian steroid hormones in the pathogenesis of uterine fibroids is supported by epidemiological, clinical, and experimental evidence. In fact, recently, Peddada et al. Near the end of each tube is an ovary. Biol Reprod. Transforming growth factor beta3 regulates the versican variants in the extracellular matrix-rich uterine leiomyomas. Acta Histochem. 2001;86:913–20. 2011;76:11–7. Retinoic acid treatment of human leiomyoma cells transformed the cell phenotype to one strongly resembling myometrial cells.